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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1950307Generated: October 30, 2026

2-Chloroethyldiisopropylammonium chloride → 6-{2-{2-[4-(2-Diisopropylaminoethoxy)phenyl]ethyl}-4-hydroxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

https://huagongshe.com/reaction/1950307

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloroethyldiisopropylammonium chlorideHCID 77942—
ReactantDiisopropyl{2-{4-{2-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]ethyl}phenoxy}ethyl}amineHCID 23087353—
Reactant4-{2-[5-Methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]ethyl}phenolHCID 57934222—
Product6-{2-{2-[4-(2-Diisopropylaminoethoxy)phenyl]ethyl}-4-hydroxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-olHCID 5793421535.8%

Reaction Steps

Synthesized from 4-{2-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]ethyl}phenol and (2-chloroethyl)diisopropylamine hydrochloride according to an analogous synthetic method to Preparation Example 40, diisopropyl {2-{4-{2-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]ethyl}phenoxy}ethyl}amine (183 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (62 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08399520B2
Source datasetuspto-grants-2013_03
ORD IDord-bb35d2d3722e4de1938ba33c8daa66e6
Source noteuspto-grants-2013_03