HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Benzyloxy)-4-ethynyl-2-fluorobenzene → 2-Fluoro-4-{2-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]ethyl}phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Benzyloxy)-4-ethynyl-2-fluorobenzene | HCID 23087216 | — |
| Reactant | 2-(2-Iodo-4-methoxyphenyl)-6-methoxy-1,2,3,4-tetrahydronaphthalene | HCID 23087559 | — |
| Reactant | 2-[2-(4-Benzyloxy-3-fluorophenylethynyl)-4-methoxyphenyl]-6-methoxy-1,2,3,4-tetrahydronaphthalene | HCID 69774550 | — |
| Product | 2-Fluoro-4-{2-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]ethyl}phenol | HCID 57934514 | 85.3% |
Reaction Steps
Synthesized from 1-benzyloxy-4-ethynyl-2-fluorobenzene and 2-(2-iodo-4-methoxyphenyl)-6-methoxy-1,2,3,4-tetrahydronaphthalene according to an analogous synthetic method to Preparation Example 45, 2-[2-(4-benzyloxy-3-fluorophenylethynyl)-4-methoxyphenyl]-6-methoxy-1,2,3,4-tetrahydronaphthalene (776 mg) was used according to an analogous synthetic method to Example 22 to provide the title compound (546 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-0b959d6c2fc646289f55be226512c528 |
| Source note | uspto-grants-2013_03 |