HRID1950320

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCN(C(=O)c1ccc(OC2CC3CCC(C2)N3C)c(F)c1)c1cc(OC)ccc1C1CCc2cc(OC)ccc2C1

HCID58023090

未命名化合物

结构：CCN(Cc1ccc(OC2CC3CCC(C2)N3C)c(F)c1)c1cc(OC)ccc1C1CCc2cc(OC)ccc2C1

HCID66628126

未命名化合物

PRODUCTS

生成物

结构：CCN(Cc1ccc(OC2CC3CCC(C2)N3C)c(F)c1)c1cc(O)ccc1C1CCc2cc(O)ccc2C1

HCID58023067

未命名化合物

PROCEDURE

实验过程

Synthesized from N-ethyl-3-fluoro-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]-4-(8-methyl-8-azabicyclo[3.2.1]oct-3-yloxy)benzamide according to an analogous synthetic method to Example 337, ethyl[3-fluoro-4-(8-methyl-8-azabicyclo[3.2.1]oct-3-yloxy)benzyl][5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine (123 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (108 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d66f65aebfdb40989125631a2090c09c
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08399520B2
来源说明: uspto-grants-2013_03

反应 SMILES

[CH2:1]([N:3]([C:23]1[CH:28]=[C:27]([O:29]C)[CH:26]=[CH:25][C:24]=1[CH:31]1[CH2:40][CH2:39][C:38]2[C:33](=[CH:34][CH:35]=[C:36]([O:41]C)[CH:37]=2)[CH2:32]1)[C:4](=O)[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH:12]2[CH2:18][CH:17]3[N:19]([CH3:20])[CH:14]([CH2:15][CH2:16]3)[CH2:13]2)=[C:7]([F:21])[CH:6]=1)[CH3:2].C(N(CC1C=CC(OC2CC3N(C)C(CC3)C2)=C(F)C=1)C1C=C(OC)C=CC=1C1CCC2C(=CC=C(OC)C=2)C1)C>>[CH2:1]([N:3]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH:12]2[CH2:13][CH:14]3[N:19]([CH3:20])[CH:17]([CH2:16][CH2:15]3)[CH2:18]2)=[C:7]([F:21])[CH:6]=1)[C:23]1[CH:28]=[C:27]([OH:29])[CH:26]=[CH:25][C:24]=1[CH:31]1[CH2:40][CH2:39][C:38]2[CH:37]=[C:36]([OH:41])[CH:35]=[CH:34][C:33]=2[CH2:32]1)[CH3:2]