N-(3-chloropropyl)piperidine hydrochloride → HCID 57934577, compound

HRID 1950323Notes

Reaction equation

HRID 1950323 reaction equation
[CH2:1]([N:3]([C:13]1[CH:18]=[C:17]([O:19]C)[CH:16]=[CH:15][C:14]=1[CH:21]1[CH2:30][CH2:29][C:28]2[C:23](=[CH:24][CH:25]=[C:26]([O:31]C)[CH:27]=2)[CH2:22]1)[C:4](=O)[C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)[CH3:2].Cl.Cl[CH2:35][CH2:36][CH2:37][N:38]1[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]1>>[CH2:1]([N:3]([CH2:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH2:35][CH2:36][CH2:37][N:38]2[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]2)=[CH:9][CH:10]=1)[C:13]1[CH:18]=[C:17]([OH:19])[CH:16]=[CH:15][C:14]=1[CH:21]1[CH2:30][CH2:29][C:28]2[CH:27]=[C:26]([OH:31])[CH:25]=[CH:24][C:23]=2[CH2:22]1)[CH3:2]

Participants

3

Reactant 2

HCID 79624N-(3-chloropropyl)piperidine hydrochlorideHCID 57934373HCID 57934373, compound

Product 1

HCID 57934577HCID 57934577, compoundYield 68.7%

Procedure

Synthesized from N-ethyl-4-hydroxy-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]benzamide (500 mg) and 1-(3-chloropropyl)piperidine hydrochloride (298 mg) according to an analogous synthetic method to Example 368, the title compound (410 mg) was obtained.

Sources & evidence

ORD record
ord-d4971d3a471b43bea8ba244ac43c8dc8
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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