HCID 66627207, compound → HCID 66627208, compound

HRID 1950325Notes

Reaction equation

HRID 1950325 reaction equation
[CH2:1]([N:3]([C:22]1[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:23]=1[CH:30]1[CH2:39][CH2:38][C:37]2[C:32](=[CH:33][CH:34]=[C:35]([O:40][CH3:41])[CH:36]=2)[CH2:31]1)[C:4](=O)[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13](=O)[N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:7][CH:6]=1)[CH3:2].[CH2:42](N(C1C=C(OC)C=CC=1C1CCC2C(=CC=C(OC)C=2)C1)CC1C=CC(OCCN2CCNCC2)=CC=1)C>>[CH2:1]([N:3]([C:22]1[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:23]=1[CH:30]1[CH2:39][CH2:38][C:37]2[C:32](=[CH:33][CH:34]=[C:35]([O:40][CH3:41])[CH:36]=2)[CH2:31]1)[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][N:17]([CH3:42])[CH2:18][CH2:19]2)=[CH:7][CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 66627207HCID 66627207, compoundHCID 66627277HCID 66627277, compound

Product 1

HCID 66627208HCID 66627208, compound

Procedure

Synthesized from N-ethyl-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]-4-(2-oxo-2-piperazin-1-ylethoxy)benzamide according to an analogous synthetic method to Example 337, ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl][4-(2-piperazin-1-ylethoxy)benzyl]amine (650 mg) was used according to an analogous synthetic method to Preparation Example 18 to provide ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]{4-[2-(4-methylpiperazin-1-yl)ethoxy]benzyl}amine (490 mg). The total amount of this compound was used according to an analogous synthetic method to Example 111 to provide the title compound (70 mg).

Workup

  1. customwas used according to an analogous synthetic method to Preparation Example 18

Sources & evidence

ORD record
ord-6c2c1635943e4a73a8424d2d6c071a85
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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