1-Chloro-2-(diethylamine)ethane hydrochloride → HCID 57934350, compound

HRID 1950326Notes

Reaction equation

HRID 1950326 reaction equation
[CH2:1]([N:3]([C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=1[CH:21]1[CH2:30][CH2:29][C:28]2[C:23](=[CH:24][CH:25]=[C:26]([O:31][CH3:32])[CH:27]=2)[CH2:22]1)[C:4](=[O:12])[C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)[CH3:2].Cl.[CH2:34]([N:36]([CH2:40][CH3:41])[CH2:37][CH2:38]Cl)[CH3:35]>>[CH2:34]([N:36]([CH2:40][CH3:41])[CH2:37][CH2:38][O:11][C:8]1[CH:7]=[CH:6][C:5]([C:4]([N:3]([CH2:1][CH3:2])[C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[CH:21]2[CH2:30][CH2:29][C:28]3[C:23](=[CH:24][CH:25]=[C:26]([O:31][CH3:32])[CH:27]=3)[CH2:22]2)=[O:12])=[CH:10][CH:9]=1)[CH3:35]

Participants

3

Reactant 2

HCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 57934373HCID 57934373, compound

Product 1

HCID 57934350HCID 57934350, compoundYield 72.5%

Procedure

Synthesized from N-ethyl-4-hydroxy-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]benzamide (250 mg) and 2-diethylaminoethyl chloride hydrochloride (130 mg) according to an analogous synthetic method to Preparation Example 40, the title compound (223 mg) was obtained.

Workup

  1. customaccording to an analogous synthetic method to Preparation Example 40

Sources & evidence

ORD record
ord-09480a64059049de86380f9b0f90d847
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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