HCID 23087137, compound → HCID 66625768, compound

HRID 1950327Notes

Reaction equation

C(N(CC)CCOC1C=CC(C([N:13]([CH2:34][CH3:35])[C:14]2[CH:19]=[C:18]([O:20]C)[CH:17]=[CH:16][C:15]=2[CH:22]2[CH2:31][CH2:30][C:29]3[C:24](=[CH:25][CH:26]=[C:27]([O:32]C)[CH:28]=3)[CH2:23]2)=O)=CC=1)C.[CH2:40]([N:42]([CH2:76][CH3:77])[CH2:43][CH2:44][O:45][C:46]1[CH:75]=[CH:74][C:49]([CH2:50]N(CC)C2C=C(OC)C=CC=2C2CCC3C(=CC=C(OC)C=3)C2)=[CH:48][CH:47]=1)[CH3:41]>>[CH2:76]([N:42]([CH2:40][CH3:41])[CH2:43][CH2:44][O:45][C:46]1[CH:47]=[CH:48][C:49]([CH2:50][CH2:35][CH2:34][NH:13][C:14]2[CH:19]=[C:18]([OH:20])[CH:17]=[CH:16][C:15]=2[CH:22]2[CH2:31][CH2:30][C:29]3[CH:28]=[C:27]([OH:32])[CH:26]=[CH:25][C:24]=3[CH2:23]2)=[CH:74][CH:75]=1)[CH3:77]

Participants

Reactant 2

HCID 23087137HCID 23087137, compound

HCID 57934350HCID 57934350, compound

Product 1

HCID 66625768HCID 66625768, compound

Procedure

Synthesized from 4-(2-diethylaminoethoxy)-N-ethyl-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]benzamide according to an analogous synthetic method to Example 337, [4-(2-diethylaminoethoxy)benzyl]ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine (149 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (159 mg).

Sources & evidence

ORD record: ord-3682e370a2914032a2e3544bfc47aae2
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399520B2

Reaction notes

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