HCID 23087282, compound → HCID 57934342, compound

HRID 1950329Notes

Reaction equation

[CH2:1]([N:3]([C:19]1[CH:24]=[C:23]([O:25]C)[CH:22]=[CH:21][C:20]=1[CH:27]1[CH2:36][CH2:35][C:34]2[C:29](=[CH:30][CH:31]=[C:32]([O:37]C)[CH:33]=2)[CH2:28]1)[C:4](=O)[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13](=O)[NH:14][CH2:15][CH3:16])=[CH:7][CH:6]=1)[CH3:2].C(N(CC1C=CC(OCCNCC)=CC=1)C1C=C(OC)C=CC=1C1CCC2C(=CC=C(OC)C=2)C1)C>>[CH2:1]([N:3]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][NH:14][CH2:15][CH3:16])=[CH:7][CH:6]=1)[C:19]1[CH:24]=[C:23]([OH:25])[CH:22]=[CH:21][C:20]=1[CH:27]1[CH2:36][CH2:35][C:34]2[CH:33]=[C:32]([OH:37])[CH:31]=[CH:30][C:29]=2[CH2:28]1)[CH3:2]

Participants

Reactant 2

HCID 23087282HCID 23087282, compound

HCID 57934379HCID 57934379, compound

Product 1

HCID 57934342HCID 57934342, compound

Procedure

Synthesized from N-ethyl-4-ethylcarbamoylmethoxy-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]benzamide according to an analogous synthetic method to Example 337, ethyl[4-(2-ethylaminoethoxy)benzyl][5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine (143 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (138 mg).

Sources & evidence

ORD record: ord-cc5ce04851e740629b88078bb80b9740
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399520B2

Reaction notes

Loading…