3-Azabicyclo(3.2.2)nonane, 3-(chloroacetyl)- → HCID 57934195, compound

HRID 1950366Notes

Reaction equation

HRID 1950366 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:36]=[CH:37][C:38]=1[OH:39])[C:5]([N:7]([CH:33]([CH3:35])[CH3:34])[C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:9]=1[CH:16]1[CH2:25][CH2:24][C:23]2[CH:22]=[C:21]([O:26]C(=O)C(C)(C)C)[CH:20]=[CH:19][C:18]=2[CH2:17]1)=O.[CH:40]12[CH2:48][CH2:47][CH:44]([CH2:45][CH2:46]1)[CH2:43][N:42]([C:49](=O)[CH2:50]Cl)[CH2:41]2>>[CH:40]12[CH2:48][CH2:47][CH:44]([CH2:45][CH2:46]1)[CH2:43][N:42]([CH2:49][CH2:50][O:39][C:38]1[CH:37]=[CH:36][C:4]([CH2:5][N:7]([CH:33]([CH3:35])[CH3:34])[C:8]3[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:9]=3[CH:16]3[CH2:25][CH2:24][C:23]4[CH:22]=[C:21]([OH:26])[CH:20]=[CH:19][C:18]=4[CH2:17]3)=[CH:3][C:2]=1[F:1])[CH2:41]2

Participants

3

Reactant 2

HCID 143313-Azabicyclo(3.2.2)nonane, 3-(chloroacetyl)-HCID 57934527Pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester

Product 1

HCID 57934195HCID 57934195, compoundYield 12%

Procedure

Synthesized from pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (25 mg) and 1-(3-azabicyclo[3.2.2]non-3-yl)-2-chloroethanone (19 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (3.3 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-cacc25bfa36c41cea406ade2d779616a
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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