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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1950378Generated: October 30, 2026

1-(2-Chloroethyl)azepane → 6-{2-{[4-(2-Azepan-1-yl-ethoxy)benzyl]isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

https://huagongshe.com/reaction/1950378

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Chloroethyl)azepaneHCID 16625—
ReactantPivalic acid 6-{2-[(4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl esterHCID 57933955—
Product6-{2-{[4-(2-Azepan-1-yl-ethoxy)benzyl]isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-olHCID 5793449019%

Reaction Steps

Synthesized from pivalic acid 6-{2-[(4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (30 mg) and 1-(2-chloroethyl)azepane (23 mg) according to an analogous synthetic method to Example 404 and purified by NH silica gel column chromatography (hexane-ethyl acetate system), the title compound (6.0 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08399520B2
Source datasetuspto-grants-2013_03
ORD IDord-b9b28e295b2543fcb427dd65503452ce
Source noteuspto-grants-2013_03