3-Azabicyclo(3.2.2)nonane, 3-(chloroacetyl)- → HCID 57934081, compound

HRID 1950382Notes

Reaction equation

HRID 1950382 reaction equation
[OH:1][C:2]1[CH:38]=[CH:37][C:5]([C:6]([N:8]([CH:34]([CH3:36])[CH3:35])[C:9]2[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:10]=2[CH:17]2[CH2:26][CH2:25][C:24]3[CH:23]=[C:22]([O:27]C(=O)C(C)(C)C)[CH:21]=[CH:20][C:19]=3[CH2:18]2)=O)=[CH:4][CH:3]=1.[CH:39]12[CH2:47][CH2:46][CH:43]([CH2:44][CH2:45]1)[CH2:42][N:41]([C:48](=O)[CH2:49]Cl)[CH2:40]2>>[CH:43]12[CH2:46][CH2:47][CH:39]([CH2:45][CH2:44]1)[CH2:40][N:41]([CH2:48][CH2:49][O:1][C:2]1[CH:38]=[CH:37][C:5]([CH2:6][N:8]([CH:34]([CH3:35])[CH3:36])[C:9]3[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:10]=3[CH:17]3[CH2:26][CH2:25][C:24]4[CH:23]=[C:22]([OH:27])[CH:21]=[CH:20][C:19]=4[CH2:18]3)=[CH:4][CH:3]=1)[CH2:42]2

Participants

3

Reactant 2

HCID 143313-Azabicyclo(3.2.2)nonane, 3-(chloroacetyl)-HCID 57933955Pivalic acid 6-{2-[(4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester

Product 1

HCID 57934081HCID 57934081, compoundYield 34.5%

Procedure

Synthesized from pivalic acid 6-{2-[(4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (21 mg) and 1-(3-azabicyclo[3.2.2]non-3-yl)-2-chloroethanone (17 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (8.0 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-6cf7dec0b0f14da68f37d8792de3458a
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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