HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-N-(2-methoxyethyl)-N-methylacetamide → 6-{2-{Isopropyl {4-{2-[(2-methoxyethyl)methylamino]ethoxy}benzyl}amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-N-(2-methoxyethyl)-N-methylacetamide | HCID 15174913 | — |
| Reactant | Pivalic acid 6-{2-[(4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 57933955 | — |
| Product | 6-{2-{Isopropyl {4-{2-[(2-methoxyethyl)methylamino]ethoxy}benzyl}amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 57934015 | 52.8% |
Reaction Steps
Synthesized from pivalic acid 6-{2-[(4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (22 mg) and 2-chloro-N-(2-methoxyethyl)-N-methylacetamide (14 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (12 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-8b93176d785648cfb4f0b45769057cc6 |
| Source note | uspto-grants-2013_03 |