HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-N-ethyl-N-methylacetamide → 6-{2-{Ethyl{4-[2-(ethylmethylamino)ethoxy]-3-fluorobenzyl}amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-N-ethyl-N-methylacetamide | HCID 22234698 | — |
| Reactant | Pivalic acid 6-{2-[ethyl(3-fluoro-4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 57934183 | — |
| Product | 6-{2-{Ethyl{4-[2-(ethylmethylamino)ethoxy]-3-fluorobenzyl}amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 57934293 | 66.7% |
Reaction Steps
Synthesized from pivalic acid 6-{2-[ethyl(3-fluoro-4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (20 mg) and 2-chloro-N-ethyl-N-methylacetamide (10 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (13 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-6dff9d0f1dc34e8a81aa40093abe5fdd |
| Source note | uspto-grants-2013_03 |