HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(3,3-dimethylpiperidin-1-yl)ethanone → 6-{2-{{4-[2-(3,3-Dimethylpiperidin-1-yl)ethoxy]-3-fluorobenzyl}methylamino}-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(3,3-dimethylpiperidin-1-yl)ethanone | HCID 23363786 | — |
| Reactant | Pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)methylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 66626888 | — |
| Product | 6-{2-{{4-[2-(3,3-Dimethylpiperidin-1-yl)ethoxy]-3-fluorobenzyl}methylamino}-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 66625919 | 50.9% |
Reaction Steps
Synthesized from pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)methylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (20 mg) and 2-bromo-1-(3,3-dimethylpiperidin-1-yl)ethanone (19 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (11 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-8b3b94be591b416da90f7ac1adcd7149 |
| Source note | uspto-grants-2013_03 |