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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1950440Generated: October 30, 2026

1-(Chloroacetyl)pyrrolidine → 6-{4-Methoxy-2-{propyl[4-(2-pyrrolidin-1-ylethoxy)benzyl]amino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

https://huagongshe.com/reaction/1950440

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Chloroacetyl)pyrrolidineHCID 88440—
ReactantPivalic acid 6-{2-[(4-hydroxybenzoyl)propylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl esterHCID 66626482—
Product6-{4-Methoxy-2-{propyl[4-(2-pyrrolidin-1-ylethoxy)benzyl]amino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-olHCID 57934316160.3%

Reaction Steps

Synthesized from pivalic acid 6-{2-[(4-hydroxybenzoyl)propylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (30 mg) and 2-chloro-1-pyrrolidin-1-ylethanone (17 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (24 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08399520B2
Source datasetuspto-grants-2013_03
ORD IDord-6cac024542e347789e1bf88e48962973
Source noteuspto-grants-2013_03