HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-1-(4-methylpiperidin-1-yl)ethan-1-one → 6-{4-Methoxy-2-{{4-[2-(4-methylpiperidin-1-yl)ethoxy]benzyl}propylamino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-1-(4-methylpiperidin-1-yl)ethan-1-one | HCID 4116926 | — |
| Reactant | Pivalic acid 6-{2-[(4-hydroxybenzoyl)propylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 66626482 | — |
| Product | 6-{4-Methoxy-2-{{4-[2-(4-methylpiperidin-1-yl)ethoxy]benzyl}propylamino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 66628094 | 60.2% |
Reaction Steps
Synthesized from pivalic acid 6-{2-[(4-hydroxybenzoyl)propylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (30 mg) and 2-chloro-1-(4-methylpiperidin-1-yl)ethanone (21 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (19 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-d819a5740c8644a4a91d50d5cfb024d0 |
| Source note | uspto-grants-2013_03 |