HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-tert-butyl-2-chloro-N-methylacetamide → 6-{2-{{4-[2-(tert-Butylmethylamino)ethoxy]benzyl}ethylamino}-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-tert-butyl-2-chloro-N-methylacetamide | HCID 15829370 | — |
| Reactant | Pivalic acid 6-{2-[ethyl(4-hydroxybenzoyl)amino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 66626109 | — |
| Product | 6-{2-{{4-[2-(tert-Butylmethylamino)ethoxy]benzyl}ethylamino}-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 66627425 | 24.6% |
Reaction Steps
Synthesized from pivalic acid 6-{2-[ethyl(4-hydroxybenzoyl)amino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (19 mg) and N-tert-butyl-2-chloro-N-methylacetamide (12 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (2.4 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-234facd1f7a94832adba1082caf10d66 |
| Source note | uspto-grants-2013_03 |