HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-N-methyl-N-(2-methylpropyl)acetamide → 6-{2-{Ethyl{3-fluoro-4-[2-(isobutylmethylamino)ethoxy]benzyl}amino}-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-N-methyl-N-(2-methylpropyl)acetamide | HCID 23087468 | — |
| Reactant | Pivalic acid 6-{2-[ethyl(3-fluoro-4-hydroxybenzoyl)amino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 66626902 | — |
| Product | 6-{2-{Ethyl{3-fluoro-4-[2-(isobutylmethylamino)ethoxy]benzyl}amino}-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 57933888 | 7.7% |
Reaction Steps
Synthesized from pivalic acid 6-{2-[ethyl(3-fluoro-4-hydroxybenzoyl)amino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (19 mg) and 2-chloro-N-isobutyl-N-methylacetamide (12 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (1.5 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-f9829a4103ab452cbc2ed073c95b23e7 |
| Source note | uspto-grants-2013_03 |