HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Azepan-1-yl)-2-chloroethan-1-one → (R)-6-{2-{[4-(2-Azepan-1-ylethoxy)benzyl]ethylamino}-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Azepan-1-yl)-2-chloroethan-1-one | HCID 3144134 | — |
| Reactant | Pivalic acid (R)-6-{2-[ethyl(4-hydroxybenzoyl)amino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 57934042 | — |
| Product | (R)-6-{2-{[4-(2-Azepan-1-ylethoxy)benzyl]ethylamino}-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 66628170 | 89.2% |
Reaction Steps
Synthesized from pivalic acid (R)-6-{2-[ethyl(4-hydroxybenzoyl)amino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (16 mg) and 1-azepan-1-yl-2-chloroethanone (9.5 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (7.5 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-d56a8afdde844c0d83eeffc048abbd2f |
| Source note | uspto-grants-2013_03 |