HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-N-methyl-N-(propan-2-yl)acetamide → (R)-6-{2-{Ethyl {3-fluoro-4-[2-(isopropylmethylamino)ethoxy]benzyl}amino}-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-N-methyl-N-(propan-2-yl)acetamide | HCID 8899730 | — |
| Reactant | Pivalic acid (R)-6-{2-[ethyl(3-fluoro-4-hydroxybenzoyl)amino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 57934194 | — |
| Product | (R)-6-{2-{Ethyl {3-fluoro-4-[2-(isopropylmethylamino)ethoxy]benzyl}amino}-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 57934164 | 49.2% |
Reaction Steps
Synthesized from pivalic acid (R)-6-{2-[ethyl(3-fluoro-4-hydroxybenzoyl)amino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (15 mg) and 2-chloro-N-isopropyl-N-methylacetamide (8.1 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (7.4 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-e9f5bbeb0de4482ba42fe97f89ec198e |
| Source note | uspto-grants-2013_03 |