HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloro-N,N-diethylacetamide → (R)-6-{2-{[4-(2-Diethylaminoethoxy)-3-fluorobenzyl]isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloro-N,N-diethylacetamide | HCID 16844 | — |
| Reactant | pivalic acid (R)-6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 57934354 | — |
| Product | (R)-6-{2-{[4-(2-Diethylaminoethoxy)-3-fluorobenzyl]isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 57933968 | 38.5% |
Reaction Steps
Synthesized from pivalic acid (R)-6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (21 mg) and 2-chloro-N,N-diethylacetamide (12 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (8.1 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-346f5f1435b54cc8a7d39b26bf647c32 |
| Source note | uspto-grants-2013_03 |