HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-N-(2-methoxyethyl)-N-methylacetamide → (R)-6-{2-{{3-Fluoro-4-{2-[(2-methoxyethyl)methylamino]ethoxy}benzyl)isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-N-(2-methoxyethyl)-N-methylacetamide | HCID 15174913 | — |
| Reactant | pivalic acid (R)-6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 57934354 | — |
| Product | (R)-6-{2-{{3-Fluoro-4-{2-[(2-methoxyethyl)methylamino]ethoxy}benzyl)isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 57934358 | 33.2% |
Reaction Steps
Synthesized from pivalic acid (R)-6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (21 mg) and 2-chloro-N-(2-methoxyethyl)-N-methylacetamide (13 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (7.2 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-f96b95856beb4c449da2a354325122c9 |
| Source note | uspto-grants-2013_03 |