HCID 45081166, compound → HCID 57934091, compound

HRID 1950569Notes

Reaction equation

HRID 1950569 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:36]=[CH:37][C:38]=1[OH:39])[C:5]([N:7]([CH:33]([CH3:35])[CH3:34])[C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:9]=1[C@@H:16]1[CH2:25][CH2:24][C:23]2[CH:22]=[C:21]([O:26]C(=O)C(C)(C)C)[CH:20]=[CH:19][C:18]=2[CH2:17]1)=O.[CH:40]12[N:46]([C:47](=O)[CH2:48]Br)[CH:43]([CH2:44][CH2:45]1)[CH2:42][CH2:41]2>>[CH:43]12[N:46]([CH2:47][CH2:48][O:39][C:38]3[CH:37]=[CH:36][C:4]([CH2:5][N:7]([CH:33]([CH3:35])[CH3:34])[C:8]4[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:9]=4[C@@H:16]4[CH2:25][CH2:24][C:23]5[CH:22]=[C:21]([OH:26])[CH:20]=[CH:19][C:18]=5[CH2:17]4)=[CH:3][C:2]=3[F:1])[CH:40]([CH2:45][CH2:44]1)[CH2:41][CH2:42]2

Participants

3

Reactant 2

HCID 45081166HCID 45081166, compoundHCID 57934354pivalic acid (R)-6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester

Product 1

HCID 57934091HCID 57934091, compoundYield 65.3%

Procedure

Synthesized from pivalic acid (R)-6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (19 mg) and 1-(7-azabicyclo[2.2.1]hept-7-yl)-2-bromoethanone (15 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (13 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-3af5286551614b29bc1d77c909ae5b2a
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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