3,3-Dimethylpiperidine → HCID 66628086, compound

HRID 1950585Notes

Reaction equation

HRID 1950585 reaction equation
[C:1]([CH2:4][C:5]1[CH:39]=[CH:38][C:8]([CH2:9][CH2:10][CH2:11][NH:12][C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[C@@H:21]2[CH2:30][CH2:29][C:28]3[CH:27]=[C:26]([O:31]C(=O)C(C)(C)C)[CH:25]=[CH:24][C:23]=3[CH2:22]2)=[CH:7][CH:6]=1)(O)=O.[CH3:40][C:41]1([CH3:47])[CH2:46][CH2:45][CH2:44][NH:43][CH2:42]1>>[CH3:40][C:41]1([CH3:47])[CH2:46][CH2:45][CH2:44][N:43]([CH2:1][CH2:4][C:5]2[CH:6]=[CH:7][C:8]([CH2:9][CH2:10][CH2:11][NH:12][C:13]3[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=3[C@@H:21]3[CH2:30][CH2:29][C:28]4[CH:27]=[C:26]([OH:31])[CH:25]=[CH:24][C:23]=4[CH2:22]3)=[CH:38][CH:39]=2)[CH2:42]1

Participants

3

Reactant 2

HCID 709423,3-DimethylpiperidineHCID 86605261HCID 86605261, compound

Product 1

HCID 66628086HCID 66628086, compoundYield 12.7%

Procedure

Synthesized from pivalic acid (R)-6-{2-[(4-carboxymethylbenzyl)ethylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (19 mg) and 3,3-dimethylpiperidine (20 mg) according to an analogous synthetic method to Example 715 and purified by LC-MS, the title compound (2.4 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-256243fcefa24fcb97ae2eaa5a2f2200
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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