7-Azabicyclo[2.2.1]heptane hydrochloride → HCID 66627262, compound

HRID 1950586Notes

Reaction equation

HRID 1950586 reaction equation
[C:1]([CH2:4][C:5]1[CH:39]=[CH:38][C:8]([CH2:9][CH2:10][CH2:11][NH:12][C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[C@@H:21]2[CH2:30][CH2:29][C:28]3[CH:27]=[C:26]([O:31]C(=O)C(C)(C)C)[CH:25]=[CH:24][C:23]=3[CH2:22]2)=[CH:7][CH:6]=1)(O)=O.Cl.[CH:41]12[NH:47][CH:44]([CH2:45][CH2:46]1)[CH2:43][CH2:42]2>>[CH:44]12[N:47]([CH2:1][CH2:4][C:5]3[CH:6]=[CH:7][C:8]([CH2:9][CH2:10][CH2:11][NH:12][C:13]4[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=4[C@@H:21]4[CH2:30][CH2:29][C:28]5[CH:27]=[C:26]([OH:31])[CH:25]=[CH:24][C:23]=5[CH2:22]4)=[CH:38][CH:39]=3)[CH:41]([CH2:46][CH2:45]1)[CH2:42][CH2:43]2

Participants

3

Reactant 2

HCID 162795037-Azabicyclo[2.2.1]heptane hydrochlorideHCID 86605261HCID 86605261, compound

Product 1

HCID 66627262HCID 66627262, compoundYield 6%

Procedure

Synthesized from pivalic acid (R)-6-{2-[(4-carboxymethylbenzyl)ethylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (19 mg) and 7-azabicyclo[2.2.1]heptane hydrochloride (20 mg) according to an analogous synthetic method to Example 715 and purified by LC-MS, the title compound (1.1 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-f6fb6af708124cb082e7b3db1280be4a
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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