HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → (R)-6-{2-{Ethyl[4-(2-piperidin-1-ylethyl)benzyl]amino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Pivalic acid (R)-6-{2-[(4-carboxymethylbenzyl)ethylamino]phenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 86605264 | — |
| Product | (R)-6-{2-{Ethyl[4-(2-piperidin-1-ylethyl)benzyl]amino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 57934202 | 57.9% |
Reaction Steps
Synthesized from pivalic acid (R)-6-{2-[(4-carboxymethylbenzyl)ethylamino]phenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (28 mg) and piperidine (24 mg) according to an analogous synthetic method to Example 715 and purified by LC-MS, the title compound (7.6 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-771a2c18336e457e88898e99a5a70d84 |
| Source note | uspto-grants-2013_03 |