HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Azabicyclo[2.2.1]heptane hydrochloride → (R)-6-{2-{{4-[2-(7-Azabicyclo[2.2.1]hept-7-yl)ethyl]benzyl}ethylamino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Azabicyclo[2.2.1]heptane hydrochloride | HCID 16279503 | — |
| Reactant | Pivalic acid (R)-6-{2-[(4-carboxymethylbenzyl)ethylamino]phenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 86605264 | — |
| Product | (R)-6-{2-{{4-[2-(7-Azabicyclo[2.2.1]hept-7-yl)ethyl]benzyl}ethylamino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 66626152 | 23% |
Reaction Steps
Synthesized from pivalic acid (R)-6-{2-[(4-carboxymethylbenzyl)ethylamino]phenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (28 mg) and 7-azabicyclo[2.2.1]heptane hydrochloride (38 mg) according to an analogous synthetic method to Example 715 and purified by LC-MS, the title compound (6.2 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-5752b2ff8735458ab9b1636ec22b18f7 |
| Source note | uspto-grants-2013_03 |