2-Chloroethyldiisopropylammonium chloride → HCID 57933808, compound

HRID 1950608Notes

Reaction equation

COC1C=C(OC2C=CC(O)=CC=2)C2CC(C3C=CC(OC)=CC=3)CCC=2C=1.Cl.ClCCN(C(C)C)C(C)C.[CH:40]([N:43]([CH:74]([CH3:76])[CH3:75])[CH2:44][CH2:45][O:46][C:47]1[CH:52]=[CH:51][C:50]([O:53][C:54]2[C:63]3[CH2:62][CH:61]([C:64]4[CH:69]=[CH:68][C:67]([O:70]C)=[CH:66][CH:65]=4)[CH2:60][CH2:59][C:58]=3[CH:57]=[C:56]([O:72]C)[CH:55]=2)=[CH:49][CH:48]=1)([CH3:42])[CH3:41]>>[CH:74]([N:43]([CH:40]([CH3:42])[CH3:41])[CH2:44][CH2:45][O:46][C:47]1[CH:52]=[CH:51][C:50]([O:53][C:54]2[C:63]3[CH2:62][CH:61]([C:64]4[CH:69]=[CH:68][C:67]([OH:70])=[CH:66][CH:65]=4)[CH2:60][CH2:59][C:58]=3[CH:57]=[C:56]([OH:72])[CH:55]=2)=[CH:49][CH:48]=1)([CH3:75])[CH3:76]

Participants

Reactant 3

HCID 779422-Chloroethyldiisopropylammonium chloride

HCID 11417530HCID 11417530, compound

HCID 23087132HCID 23087132, compound

Product 1

HCID 57933808HCID 57933808, compoundYield 22.3%

Procedure

Synthesized from 4-[3-methoxy-7-(4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-1-yloxy]phenol and (2-chloroethyl)diisopropylamine hydrochloride according to an analogous synthetic method to Preparation Example 40, diisopropyl{2-{4-[3-methoxy-7-(4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-1-yloxy]phenoxy}ethyl}amine (408 mg) was used according to an analogous synthetic method to Example 779 described below to provide the title compound (86 mg).

Sources & evidence

ORD record: ord-6a9489358002430f9189d29f7a8ee108
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399520B2

Reaction notes

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