Piperidine, 1-(2-chloroethyl)-, hydrochloride → HCID 11396016, compound

HRID 1950618Notes

Reaction equation

HRID 1950618 reaction equation
COC1C=CC(CC2C=CC(OC)=CC=2)=C(C=1)OC1C=CC(O)=CC=1.Cl.ClCCN1CCCCC1.C[O:37][C:38]1[CH:39]=[CH:40][C:41]([CH2:60][C:61]2[CH:66]=[CH:65][C:64]([O:67]C)=[CH:63][CH:62]=2)=[C:42]([CH:59]=1)[O:43][C:44]1[CH:58]=[CH:57][C:47]([O:48][CH2:49][CH2:50][N:51]2[CH2:56][CH2:55][CH2:54][CH2:53][CH2:52]2)=[CH:46][CH:45]=1>>[OH:67][C:64]1[CH:65]=[CH:66][C:61]([CH2:60][C:41]2[CH:40]=[CH:39][C:38]([OH:37])=[CH:59][C:42]=2[O:43][C:44]2[CH:58]=[CH:57][C:47]([O:48][CH2:49][CH2:50][N:51]3[CH2:52][CH2:53][CH2:54][CH2:55][CH2:56]3)=[CH:46][CH:45]=2)=[CH:62][CH:63]=1

Participants

4

Reactant 3

HCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 11163490HCID 11163490, compoundHCID 66627685HCID 66627685, compound

Product 1

HCID 11396016HCID 11396016, compoundYield 28.2%

Procedure

Synthesized from 4-[5-methoxy-2-(4-methoxybenzyl)phenoxy]phenol and 1-(2-chloroethyl)piperidine hydrochloride according to an analogous synthetic method to Preparation Example 40, 1-{2-{4-[5-methoxy-2-(4-methoxybenzyl)phenoxy]phenoxy}ethyl}piperidine (223 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (59 mg).

Sources & evidence

ORD record
ord-606bf31888a6409baa8b3f59511c3d54
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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