4-Benzyloxy-phenylboronic acid → HCID 11370629, compound

HRID 1950622Notes

Reaction equation

HRID 1950622 reaction equation
FC(F)(F)S(OC1C=C(OC)C=CC=1CC1C=CC=C(OC)C=1)(=O)=O.C(OC1C=CC(B(O)O)=CC=1)C1C=CC=CC=1.C([O:50][C:51]1[CH:56]=[CH:55][C:54]([C:57]2[CH:62]=[C:61]([O:63][CH3:64])[CH:60]=[CH:59][C:58]=2[CH2:65][C:66]2[CH:71]=[CH:70][CH:69]=[C:68]([O:72][CH3:73])[CH:67]=2)=[CH:53][CH:52]=1)C1C=CC=CC=1>>[CH3:64][O:63][C:61]1[CH:60]=[CH:59][C:58]([CH2:65][C:66]2[CH:71]=[CH:70][CH:69]=[C:68]([O:72][CH3:73])[CH:67]=2)=[C:57]([C:54]2[CH:53]=[CH:52][C:51]([OH:50])=[CH:56][CH:55]=2)[CH:62]=1

Participants

4

Reactant 3

HCID 27343144-Benzyloxy-phenylboronic acidHCID 11394754HCID 11394754, compoundHCID 23087527HCID 23087527, compound

Product 1

HCID 11370629HCID 11370629, compoundYield 64.5%

Procedure

Synthesized from 5-methoxy-2-(3-methoxybenzyl)phenyl trifluoromethanesulfonate and 4-benzyloxyphenylboronic acid according to an analogous synthetic method to Example 24, 4′-benzyloxy-5-methoxy-2-(3-methoxybenzyl)biphenyl (332 mg) was used according to an analogous synthetic method to Example 22 to provide the title compound (167 mg).

Sources & evidence

ORD record
ord-8348ee6f59824a4d98f51b294183466d
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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