HCID 23087116, compound → HCID 57934131, compound

HRID 1950635Notes

Reaction equation

COC1C=C2C(=CC=1)CC(CC1C=CC=CC=1NCC1C=CC(OCCN3CCCCC3)=CC=1)CC2.[CH2:37]([N:39]([C:56]1[CH:61]=[CH:60][CH:59]=[CH:58][C:57]=1[CH2:62][CH:63]1[CH2:72][CH2:71][C:70]2[C:65](=[CH:66][CH:67]=[C:68]([O:73]C)[CH:69]=2)[CH2:64]1)[CH2:40][C:41]1[CH:46]=[CH:45][C:44]([O:47][CH2:48][CH2:49][N:50]2[CH2:55][CH2:54][CH2:53][CH2:52][CH2:51]2)=[CH:43][CH:42]=1)[CH3:38]>>[CH2:37]([N:39]([CH2:40][C:41]1[CH:46]=[CH:45][C:44]([O:47][CH2:48][CH2:49][N:50]2[CH2:55][CH2:54][CH2:53][CH2:52][CH2:51]2)=[CH:43][CH:42]=1)[C:56]1[CH:61]=[CH:60][CH:59]=[CH:58][C:57]=1[CH2:62][CH:63]1[CH2:72][CH2:71][C:70]2[CH:69]=[C:68]([OH:73])[CH:67]=[CH:66][C:65]=2[CH2:64]1)[CH3:38]

Participants

Reactant 2

HCID 23087116HCID 23087116, compound

HCID 23087355HCID 23087355, compound

Product 1

HCID 57934131HCID 57934131, compoundYield 47.2%

Procedure

Synthesized from [2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)phenyl][4-(2-piperidin-1-ylethoxy)benzyl]amine (600 mg) according to an analogous synthetic method to Example 786, ethyl[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)phenyl][4-(2-piperidin-1-ylethoxy)benzyl]amine (370 mg) was used according to an analogous synthetic method to Example 364 to provide the title compound (170 mg).

Sources & evidence

ORD record: ord-ecaf279d1f654a5382b3816dae3e3f9d
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399520B2

Reaction notes

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