HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Carboxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester → (R)-6-{2-{2-Hydroxyethyl[4-(1-methylpiperidin-4-yl)benzyl]amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Carboxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 22492859 | — |
| Reactant | HCID 57934485 | HCID 57934485 | — |
| Product | (R)-6-{2-{2-Hydroxyethyl[4-(1-methylpiperidin-4-yl)benzyl]amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 57933964 | 45.1% |
Reaction Steps
Synthesized from pivalic acid (R)-6-[2-(ethoxycarbonylmethylamino)-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-yl ester (35 mg) and 4-(4-carboxyphenyl)piperidine-1-carboxylic acid tert-butyl ester (73 mg) according to an analogous synthetic method to the above-mentioned Preparation Example 86 and Example 337, the title compound (18 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-ec29e8603f104ed59e9ed2bfb28cf62a |
| Source note | uspto-grants-2013_03 |