HCID 57934253, compound → HCID 57934023, compound

HRID 1950648Notes

Reaction equation

[CH2:1]([NH:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[C@@H:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([O:22]C(=O)C(C)(C)C)[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2].C(OC([CH2:36][CH2:37][NH:38][C:39]([CH3:51])([CH3:50])[CH2:40][C:41]1[CH:49]=[CH:48][C:44]([C:45](O)=O)=[CH:43][CH:42]=1)=O)(C)(C)C.C(OC(CCNC(C)(C)CC1C=CC(C(CCNC2C=C(OC)C=CC=2C2CCC3C=C(OC(=O)C(C)(C)C)C=CC=3C2)=O)=CC=1)=O)(C)(C)C>>[CH2:1]([N:3]([CH2:45][C:44]1[CH:48]=[CH:49][C:41]([CH2:40][C:39]([NH:38][CH2:37][CH3:36])([CH3:51])[CH3:50])=[CH:42][CH:43]=1)[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[C@@H:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([OH:22])[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2]

Participants

Reactant 3

HCID 57934253HCID 57934253, compound

HCID 66625977HCID 66625977, compound

HCID 66627376HCID 66627376, compound

Product 1

HCID 57934023HCID 57934023, compoundYield 43.1%

Procedure

Synthesized from pivalic acid (R)-6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (100 mg) and 4-[2-(tert-butoxycarbonylethylamino)-2-methylpropyl]benzoic acid (125 mg) according to analogous synthetic method to Preparation Example 86, pivalic acid 6-{2-{{4-[2-(tert-butoxycarbonylethylamino)-2-methylpropyl]benzoyl}ethylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (94 mg) was used according to an analogous synthetic method to the above-mentioned Example 215 and Example 337 to provide the title compound (55 mg).

Sources & evidence

ORD record: ord-147620f25bb640ed809bb014b158d3db
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399520B2

Reaction notes

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