HCID 57934253, compound → HCID 66625603, compound

HRID 1950649Notes

Reaction equation

HRID 1950649 reaction equation
[CH2:1]([NH:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[C@@H:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([O:22]C(=O)C(C)(C)C)[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2].C(OC([CH2:36][NH:37][C:38]([CH3:50])([CH3:49])[CH2:39][C:40]1[CH:48]=[CH:47][C:43]([C:44](O)=O)=[CH:42][CH:41]=1)=O)(C)(C)C.[C:51](OC(CNC(C)(C)CC1C=CC(C(CCNC2C=C(OC)C=CC=2C2CCC3C=C(OC(=O)C(C)(C)C)C=CC=3C2)=O)=CC=1)=O)(C)(C)C>>[CH3:51][N:37]([CH3:36])[C:38]([CH3:49])([CH3:50])[CH2:39][C:40]1[CH:41]=[CH:42][C:43]([CH2:44][CH2:2][CH2:1][NH:3][C:4]2[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=2[C@@H:12]2[CH2:21][CH2:20][C:19]3[CH:18]=[C:17]([OH:22])[CH:16]=[CH:15][C:14]=3[CH2:13]2)=[CH:47][CH:48]=1

Participants

4

Reactant 3

HCID 57934253HCID 57934253, compoundHCID 66627623HCID 66627623, compoundHCID 66627950HCID 66627950, compound

Product 1

HCID 66625603HCID 66625603, compoundYield 37%

Procedure

Synthesized from pivalic acid (R)-6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (100 mg) and 4-[2-(tert-butoxycarbonylmethylamino)-2-methylpropyl]benzoic acid (120 mg) according to an analogous synthetic method to Preparation Example 86, pivalic acid 6-{2-{{4-[2-(tert-butoxycarbonylmethylamino)-2-methylpropyl]benzoyl}ethylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (67 mg) was used according to an analogous synthetic method to Example 337 to provide the title compound (18 mg).

Sources & evidence

ORD record
ord-28384a2a0cbd4b97a1e5d413784e5693
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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