Benzyl Alcohol → 1-(Phenylmethyl) 4-carboxybenzeneacetate

HRID 1950653Notes

Reaction equation

HRID 1950653 reaction equation
C(C1C=CC(CC(O)=O)=CC=1)=[O:2].C(O)C1C=CC=CC=1.[CH:21]([C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[O:31])=[CH:25][CH:24]=1)=[O:22]>>[CH2:33]([O:32][C:30]([CH2:29][C:26]1[CH:25]=[CH:24][C:23]([C:21]([OH:2])=[O:22])=[CH:28][CH:27]=1)=[O:31])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

Participants

4

Reactant 3

HCID 244Benzyl AlcoholHCID 113441872-(4-formylphenyl)acetic AcidHCID 19966221HCID 19966221, compound

Product 1

HCID 199660801-(Phenylmethyl) 4-carboxybenzeneacetateYield 80.6%

Procedure

Synthesized from (4-formylphenyl)acetic acid (1 g) and benzyl alcohol (730 mg) according to an analogous synthetic method to Example 806, benzyl (4-formylphenyl)acetate (1.4 g) was used according to an analogous synthetic method to Preparation Example 53 to provide the title compound (1.2 g).

Workup

  1. customwas used according to an analogous synthetic method to Preparation Example 53

Sources & evidence

ORD record
ord-c45b78abdee74abfaacf72d90fd3e6ec
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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