Ammonia → HCID 66628106, compound

HRID 1950655Notes

Reaction equation

HRID 1950655 reaction equation
[C:1]([CH2:4][C:5]1[CH:39]=[CH:38][C:8]([CH2:9][CH2:10][CH2:11][NH:12][C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[C@@H:21]2[CH2:30][CH2:29][C:28]3[CH:27]=[C:26]([O:31]C(=O)C(C)(C)C)[CH:25]=[CH:24][C:23]=3[CH2:22]2)=[CH:7][CH:6]=1)(O)=O.[NH3:40]>C(Cl)(Cl)Cl>[NH2:40][CH2:1][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:9][CH2:10][CH2:11][NH:12][C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[C@@H:21]2[CH2:30][CH2:29][C:28]3[CH:27]=[C:26]([OH:31])[CH:25]=[CH:24][C:23]=3[CH2:22]2)=[CH:38][CH:39]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86605261HCID 86605261, compound

Product 1

HCID 66628106HCID 66628106, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Synthesized from pivalic acid (R)-6-{2-[(4-carboxymethylbenzyl)ethylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (31 mg) and a saturated ammonia solution in chloroform (0.1 ml) according to an analogous synthetic method to Example 806, the title compound (0.7 mg) was obtained.

Sources & evidence

ORD record
ord-695d61f262024b509ec7c2b2608fd05c
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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