HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1950746Generated: November 2, 2026
Morpholine → 4-(2,6-Difluoro-4-nitrophenyl)morpholine
https://huagongshe.com/reaction/1950746
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,2,3-Trifluoro-5-nitrobenzene | HCID 2782793 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 4-(2,6-Difluoro-4-nitrophenyl)morpholine | HCID 22385630 | — |
Reaction Steps
5.10 mL morpholine are dissolved in 1 mL 1-methyl-2-pyrrolidon and combined with 14.99 mL N,N-diisopropylethylamine and 1.85 mL 3,4,5-trifluoronitrobenzene. The reaction mixture is stirred for 1 h at 110° C. After cooling the reaction mixture is diluted with 70 mL water and 15 mL concentrated aqueous HCl solution are added. The precipitate formed is filtered off, with water washed and dissolved with ethyl acetate. Then the solvent is eliminated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08404674B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-b6375a40d2604ebaa75529dc631e0ccd |
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| Source note | uspto-grants-2013_03 |
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