HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2,6-Difluoro-4-nitrophenyl)morpholine → 3,5-Difluoro-4-(morpholin-4-yl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2,6-Difluoro-4-nitrophenyl)morpholine | HCID 22385630 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3,5-Difluoro-4-(morpholin-4-yl)aniline | HCID 21878168 | — |
Reaction Steps
3.88 g of 4-(2,6-difluoro-4-nitro-phenyl)-morpholine are dissolved in 50 mL methanol and combined with Pd/C. The mixture is hydrogenated for 18 h at 7 bar hydrogen pressure. Then the catalyst is filtered off and the solvent is eliminated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404674B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-4964cd204bd74c42a3ec9dd49f9b2112 |
| Source note | uspto-grants-2013_03 |