1-Bromo-2-fluorobenzene → HCID 68158318, compound

HRID 1950765Notes

Reaction equation

HRID 1950765 reaction equation
[F:1][CH2:2][C:3]1[C@H:7]2[CH2:8][O:9][CH2:10][C@H:6]2[O:5][N:4]=1.Br[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[F:18]>>[F:1][CH2:2][C@@:3]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])[C@H:7]2[CH2:8][O:9][CH2:10][C@H:6]2[O:5][NH:4]1

Participants

3

Reactant 2

HCID 612591-Bromo-2-fluorobenzeneHCID 68158539HCID 68158539, compound

Product 1

HCID 68158318HCID 68158318, compound

Procedure

Intermediate VI-2: Starting from (3aS,6aS)-rel-3-fluoromethyl-3a,4,6,6a-tetrahydro-furo[3,4-d]isoxazole and 1-bromo-2-fluorobenzene, the product (3S,3aS,6aS)-rel-3-fluoromethyl-3-(2-fluoro-phenyl)-hexahydro-furo[3,4-d]isoxazole was obtained as a light yellow oil. MS: m/z=242.1 [M+H]+.

Sources & evidence

ORD record
ord-ea633b11911c4a07a6c12fe2188c7dad
Source dataset
uspto-grants-2013_03
Patent number
US08404680B2

Reaction notes

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