1-Bromo-2-fluorobenzene → HCID 68157849, compound

HRID 1950766Notes

Reaction equation

HRID 1950766 reaction equation
[F:1][CH:2]([F:11])[C:3]1[C@H:7]2[CH2:8][O:9][CH2:10][C@H:6]2[O:5][N:4]=1.Br[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[F:19]>>[F:11][CH:2]([F:1])[C@@:3]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[F:19])[C@H:7]2[CH2:8][O:9][CH2:10][C@H:6]2[O:5][NH:4]1

Participants

3

Reactant 2

HCID 612591-Bromo-2-fluorobenzeneHCID 68158381HCID 68158381, compound

Product 1

HCID 68157849HCID 68157849, compound

Procedure

Intermediate VI-3: Starting from (3aS,6aS)-rel-3-difluoromethyl-3a,4,6,6a-tetrahydro-furo[3,4-d]isoxazole and 1-bromo-2-fluorobenzene, the product (3S,3aS,6aS)-rel-3-difluoromethyl-3-(2-fluorophenyl)-hexahydro-furo[3,4-d]isoxazole was obtained as an orange oil. MS: m/z=260.2 [M+H]+.

Sources & evidence

ORD record
ord-701db5c104f2458398bc4897ea8a0a9a
Source dataset
uspto-grants-2013_03
Patent number
US08404680B2

Reaction notes

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