5-(2,2,2-Trifluoroethoxy)pyrazine-2-carboxylic acid → 5-(2,2,2-Trifluoro-ethoxy)-pyrazine-2-carboxylic acid [3-((3aS,7S,7aS)-5-amino-7-methyl-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-4-fluoro-phenyl]-amide

Participants

Reaction Steps

The coupling of (3aS,7S,7aS)-7-(5-amino-2-fluoro-phenyl)-7-methyl-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-5-ylamine and 5-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid (prepared as described in Suzuki Y. et al., WO 2009/091 016) following procedure G yielded the title compound as a colorless solid. MS: m/z=470.2 [M+H]+.

Provenance & Evidence