HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Cyclopropylmethoxy)pyridine-2-carboxylic acid → 5-Cyclopropylmethoxy-pyridine-2-carboxylic acid [3-((3aS,7S,7aS)-5-amino-7-methyl-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-4-fluoro-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Cyclopropylmethoxy)pyridine-2-carboxylic acid | HCID 66691895 | — |
| Reactant | (3aS,7S,7aS)-7-(5-amino-2-fluoro-phenyl)-7-methyl-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-5-ylamine | HCID 68158132 | — |
| Product | 5-Cyclopropylmethoxy-pyridine-2-carboxylic acid [3-((3aS,7S,7aS)-5-amino-7-methyl-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-4-fluoro-phenyl]-amide | HCID 60148855 | — |
Reaction Steps
The coupling of (3aS,7S,7aS)-7-(5-amino-2-fluoro-phenyl)-7-methyl-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-5-ylamine and 5-cyclopropylmethoxy-pyridine-2-carboxylic acid (prepared as described in Scott, J. et al., WO 2011/044181) following procedure G yielded the title compound as a colorless solid. MS: m/z=441.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404680B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-beae9a57f60d4d6b8dfa47af8d7d6a54 |
| Source note | uspto-grants-2013_03 |