HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86658937, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | tert-butyl (3S)-3-aminopyrrolidine-1-carboxylate | HCID 854071 | — |
| Reactant | HCID 58494225 | HCID 58494225 | — |
| Product | HCID 86658937 | HCID 86658937 | 52% |
Reaction Steps
Compound No. 125 was prepared as described in Example 1g by starting from 2-(methylthio)-4-(4-phenoxy phenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one (87 mg, 0.23 mmol) and (S)-(−)-1-boc-3-amino pyrrolidine (129 mg, 0.69 mmol) and treating with 4 N HCl in dioxane continuing until the reaction yielded the title compound (54 mg, 52%). MS m/z: 415 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404677B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-92d9cd5b8a6a42babc9c38e9b2aa7f69 |
| Source note | uspto-grants-2013_03 |