N-bromobutanimide → HCID 58494211, compound

Participants

Reaction Steps

A 20 mL reaction vessel was charged with 2-(methylthio)-4-(3-(trifluoromethyl)phenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one (135 mg, 0.38 mmol), and N-bromosuccinimide (68 mg, 0.38 mmol) in 7 mL dry DMF. The reaction mixture was stirred at room temperature for 2 hours. The solvent was removed under reduced pressuring yielding yellow residue. The residue was recrystallized from acetonitrile providing yellow solid (100 mg, 74%). MS m/z: 431, 433 (M+H)+.

Provenance & Evidence