N-bromobutanimide → HCID 52935009, compound

HRID 1950794Notes

Reaction equation

[OH:1][C:2]1([CH2:32][OH:33])[CH2:7][CH2:6][N:5]([C:8]2[N:9]=[C:10]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([C:28]([F:31])([F:30])[F:29])[CH:21]=3)[C:11]3[C:17](=[O:18])[NH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH2:4][CH2:3]1.[Br:34]N1C(=O)CCC1=O>>[Br:34][C:14]1[C:12]2[N:13]=[C:8]([N:5]3[CH2:6][CH2:7][C:2]([OH:1])([CH2:32][OH:33])[CH2:3][CH2:4]3)[N:9]=[C:10]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([C:28]([F:30])([F:29])[F:31])[CH:21]=3)[C:11]=2[C:17](=[O:18])[NH:16][CH:15]=1

Participants

Reactant 2

HCID 67184N-bromobutanimide

HCID 58494253HCID 58494253, compound

Product 1

HCID 52935009HCID 52935009, compound

Procedure

The title compound was prepared as described in Example 183a by starting from 2-(4-hydroxy-4-(hydroxylmethyl)piperidin-1-yl)-4-(4-methoxy-3-(trifluoromethyl)phenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one and N-bromosuccinimide and continuing until the reaction yielded the title compound as pale brown solid. MS m/z: 544 and 546 (M+H)+.

Workup

customThe title compound was prepared

Sources & evidence

ORD record: ord-94a0878a9c904b3aa9dd41f1cc7e160a
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08404677B2

Reaction notes

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