HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl 4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)benzoate. Hydrochloride salt → 4-(2-Methylpiperidin-1-YL)-3-(trifluoromethyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl 4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)benzoate. Hydrochloride salt | HCID 118158357 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 4-(2-Methylpiperidin-1-YL)-3-(trifluoromethyl)benzoic acid | HCID 59495655 | 85% |
Reaction Steps
A solution of methyl 4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)benzoate. Hydrochloride salt (25 g, 74 mmol) in HCl 4M (200 mL) was stirred at 100° C. for 16 hours. After cooling to room temperature, the precipitate was filtered off and dried under vacuum to afford the title compound (18 g, 85%) of as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404676B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-0d6e2d3a2688483aaf7d79dcef754163 |
| Source note | uspto-grants-2013_03 |