HCID 16016024, compound → HCID 25255971, compound

Participants

Reaction Conditions

Reaction Steps

Stannous chloride dihydrate (147.53 mg; 0.65 mmol; 5 eq.) was added to a solution of example 2 (50 mg; 0.13 mmol; 1 eq.) in EtOH (10 mL), and the reaction mixture was stirred at 70° C. for 3 hours. After cooling, the solution was partitioned between ethyl acetate and aqueous NaHCO3. The organic layer was washed four times with brine, dried over magnesium sulfate and concentrated in vacuo to give a yellow solid. The latter was triturated in Et2O and filtrated to afford the title compound (38 mg, 82%) as a pale yellow solid.

Provenance & Evidence