HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 5-(2'-Methyl-2-nitrobiphenyl-4-YL)-3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N'-hydroxy-2-(trifluoromethoxy)benzenecarboximidamide | HCID 2794708 | — |
| Reactant | 2'-Methyl-2-nitro-[1,1'-biphenyl]-4-carboxylic acid | HCID 59495810 | — |
| Product | 5-(2'-Methyl-2-nitrobiphenyl-4-YL)-3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole | HCID 25256390 | — |
Reaction Steps
Oxalyl chloride (118 μL; 1.40 mmol; 3 eq.), Intermediate 22 (120 mg; 0.47 mmol; 1 eq.), Intermediate 2 (103 mg; 0.47 mmol, 1 eq.) and DIEA (103 μL; 1.40 mmol; 3 eq.) were reacted according to general procedure 2. Purification by column chromatography (c-hexane/ethyl acetate, 90/10) afforded the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404676B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-6d29652397b4487bba0ceeda293d0a79 |
| Source note | uspto-grants-2013_03 |