4-(Trifluoromethyl)benzoic acid → Benzoic acid, 2-(methylthio)-4-(trifluoromethyl)-

HRID 1950893Notes

Reaction equation

CO[C:3]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[C:8]([S:16][CH3:17])[C:4]=1[C:5]([OH:7])=[O:6].FC(F)(F)C1C=CC(C(O)=O)=CC=1.CSSC>>[CH3:17][S:16][C:8]1[CH:9]=[C:10]([C:12]([F:13])([F:14])[F:15])[CH:11]=[CH:3][C:4]=1[C:5]([OH:7])=[O:6]

Participants

Reactant 3

HCID 99664-(Trifluoromethyl)benzoic acid

HCID 12232Dimethyl Disulfide

HCID 591979212-Methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoic acid

Product 1

HCID 11085762Benzoic acid, 2-(methylthio)-4-(trifluoromethyl)-

Procedure

The title compound, white solid, MS: m/e=235.0 [(M−H)−], was prepared in accordance with the general method of intermediate A from 4-(trifluoromethyl)benzoic acid and dimethyl disulfide.

Sources & evidence

ORD record: ord-d9386ea36d6947d8a74d1ac6cb46726e
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08404673B2

Reaction notes

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