HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-iodo-4-(trifluoromethyl)benzoate → 2-Cyclobutyl-4-trifluoromethyl-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-iodo-4-(trifluoromethyl)benzoate | HCID 59438424 | — |
| Reactant | 2-Cyclopropyl-4-(trifluoromethyl)benzoic acid | HCID 59438485 | — |
| Reactant | HCID 178419766 | HCID 178419766 | — |
| Product | 2-Cyclobutyl-4-trifluoromethyl-benzoic acid | HCID 59438432 | — |
Reaction Steps
The title compound, white solid, MS: m/e=243.0 [(M−H)−], was prepared in accordance with the general method of intermediate K from 2-iodo-4-trifluoromethyl-benzoic acid methyl Ester and cyclobutylzincbromide followed by saponification with sodium hydroxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404673B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-47c73a74da4649859ec1a96af7160d35 |
| Source note | uspto-grants-2013_03 |